Abstract
BackgroundAbdominal tuberculosis is a severe extrapulmonary tuberculosis, which can lead to serious complications. Early diagnosis and treatment are very important for the prognosis and the diagnosis of abdominal tuberculosis is still difficult. This study aims to evaluate the diagnostic accuracy of nucleic acid amplification tests (NAATs) for abdominal tuberculosis using meta-analysis method.MethodsWe will search PubMed, the Cochrane Library, Embase, China National Knowledge Infrastructure, and the Wanfang database for studies evaluating the diagnostic accuracy of NAATs for abdominal tuberculosis until May 2020. We will include a systematic review and meta-analysis that evaluated the accuracy of NAATs for abdominal tuberculosis. Any types of study design with full text will be sought and included. The risk of bias will be assessed using the Quality Assessment of Diagnostic Accuracy Studies tool. Stata version 15.0 with the midas command packages will be used to carry out meta-analyses.ResultsThe results will provide clinical evidence for diagnostic accuracy of NAATs for abdominal tuberculosis, and this systematic review and meta-analysis will be submitted to a peer-reviewed journal for publication.ConclusionThis overview will provide evidence of NAATs for diagnosis of abdominal tuberculosis.Systematic review registrationINPLASY202060030.
Highlights
Tuberculosis (TB) is a serious threat to global health [1]
Diagnosis and treatment are very important for the prognosis and the diagnosis of abdominal tuberculosis is still difficult
This study aims to evaluate the diagnostic accuracy of nucleic acid amplification tests (NAATs) for abdominal tuberculosis using meta-analysis method
Summary
Tuberculosis (TB) is a serious threat to global health [1]. Severe types of extrapulmonary tuberculosis (EPTB) increase tuberculosis-related mortality, especially in immunodeficient populations. Abdominal tuberculosis is a common serious EPTB [2]. Abdominal tuberculosis can cause many complications, such as intestinal obstruction, intestinal perforation, which seriously affect the quality of life and prognosis of patients [3]. Early diagnosis and treatment of abdominal tuberculosis is very important to reduce the incidence of serious abdominal complications. Crohn’s disease (CD), inflammatory bowel disease (IBD) and abdominal tuberculosis have similar clinical presentations and pathologies [4]. It is easy to misdiagnose abdominal tuberculosis as CD and IBD, delaying the treatment. The diagnosis of abdominal tuberculosis is still challenging. Abdominal tuberculosis is a severe extrapulmonary tuberculosis, which can lead to serious complications. Diagnosis and treatment are very important for the prognosis and the diagnosis of abdominal tuberculosis is still difficult. This study aims to evaluate the diagnostic accuracy of nucleic acid amplification tests (NAATs) for abdominal tuberculosis using meta-analysis method
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