Abstract
sBackgroundThe aim of this study was to systematically evaluate the diagnostic performance of nCD64 for neonatal sepsis.MethodsComputer retrieval was conducted for the databases of PubMed, Embase, and Springer databases up to March 18, 2015 to select the relevant studies on nCD64 and neonatal sepsis. Sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and 95 % confidence intervals (CI) for diagnostic efficiency of nCD64 were pooled. In addition, the summary receiver operating characteristic (SROC) curve was also conducted based on the sensitivity and specificity.ResultsSeventeen studies including 3478 participants were included in this meta-analysis. The overall pooled sensitivity, specificity, PLR, NLR and DOR were 0.77 (95 % CI: 0.74–0.79), 0.74 (95 % CI: 0.72–0.75), 3.58 (95 % CI: 2.85–4.49), 0.29 (95 % CI: 0.22–0.37) and 15.18 (95 % CI: 9.75–23.62), respectively. In addition, the area under the SROC curve (AUC) was 0.8666, and no threshold effect was found based on the Spearman correlation analysis (P = 0.616). Besides, subgroup analysis showed higher sensitivity, specificity and AUC in term infants and proven infection group than those in preterm infants and clinical infection group, respectively.ConclusionsThe n CD64 expression alone is not a satisfactory marker for diagnosing neonatal sepsis with relatively low sensitivity, specificity, PLR and NLR, in spite of relatively high SROC area. Therefore, the n CD64 expression used in diagnosis of neonatal sepsis should be treated with caution.
Highlights
The aim of this study was to systematically evaluate the diagnostic performance of neutrophil CD64 (nCD64) for neonatal sepsis
Seventeen studies including 3478 participants were included in this meta-analysis
The area under the summary receiver operating characteristic (SROC) curve (AUC) was 0.8666, and no threshold effect was found based on the Spearman correlation analysis (P = 0.616)
Summary
The aim of this study was to systematically evaluate the diagnostic performance of nCD64 for neonatal sepsis. Neonatal sepsis is one of the important causes of neonatal mortality. Despite the improvement in management of newborn infant, the mortality caused by neonatal sepsis remains high (~10 %) [1]. It is difficult to diagnose neonatal sepsis during early stage because of the nonspecific and variable clinical symptoms. Blood culture is the current golden standard for confirming the neonatal sepsis. The results of blood culture could be available within 24–48 h of culture. The antibiotics would be discontinued if the blood culture results were negative by 48 h [2, 3].
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