Meta-analyses on the association of MTR A2756G and MTRR A66G polymorphisms with neural tube defect risks in Caucasian children

Abstract

Objective: Methionine synthase (MTR) and MTR reductase (MTRR) genes have been considered to be implicated in the development of neural tube defects (NTDs). The associations between MTR A2756G and MTRR A66G polymorphisms and NTD risk in children have been investigated in many studies. However, results are inconsistent. Accordingly, we conducted meta-analyses to further investigate such associations.Methods: Published literatures were obtained from PubMed and Embase databases. All studies evaluating the association between MTR A2756G or MTRR A66G polymorphism and infant NTDs were included. Pooled odds ratio with a 95% confidence interval was calculated using fixed or random-effects model.Results: A total of 13 studies (1298 cases and 2237 controls) on MTR A2756G polymorphism and 10 studies (1358 cases and 2169 controls) on MTRR A66G polymorphism were included. Meta-analyses reveal no significant association of MTR A2756G and MTRR A66G polymorphisms with risk for NTDs in Caucasian children in either the genetic model or allele model.Conclusions: The present meta-analyses indicate that MTR A2756G and MTRR A66G polymorphism are not associated with NTD risks in Caucasian children.