Abstract
The calpain-10 gene (CAPN10) was the first gene identified to be associated with Type 2 diabetes mellitus. Several polymorphic loci of the calpain-10 gene (CAPN10) have been implicated in the etiology of Type 2 diabetes mellitus. However, the results have been conflicting. Keeping this in view, the present study was aimed at doing a meta-analysis to dig out the association of CAPN SNP 44 (rs2975760) polymorphism with type 2 diabetes mellitus, given that the role of polymorphism at this particular locus is lesser studied than the rest and therefore shrouded in speculations.Preferred Reporting Items for Systematic Reviews and Meta-analyses PRISMA and the published PROSPERO research protocol was followed for the present study. A total of thirteen studies were included for pooling of data. All statistical analyses were done on R studio (version 4.2.3). The meta-analysis has lead to the conclusion that the genotype ‘CC' has significantly low odds of occurrence in the type 2 diabetes mellitus patients in the Middle Eastern Populations. Therefore, we postulate that the minor allele ‘C' must be playing a protective role against type 2 diabetes mellitus. However, the question of how the ‘CC' genotype must be affecting the incidence of T2DM only the Middle Eastern populations remains to be answered.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
