Meta analysis on the tolerance and prognosis of nasogastric feeding versus nasojejunal feeding in severe acute pancreatitis

Abstract

Objective To compare the safety and efficiency of nasogastric (NG) feeding with nasojejunal (NJ)feeding in treating severe acute pancreatitis (SAP). Methods The terms NG tube , NJ tube , SAP and enteral nutrition were used for literature search in PubMed, Embase, Cochrane Library, WanFang and CNKI databases and the publication deadline was June 1, 2016. Random effect model was used for Meta analysis. Results A total of 5 random clinical trials involving 264 patients (136 in NG group and 128 in NJ group) were included. There was no statistical difference on the incidence of adverse events (mortality: RR=0.77, 95%CI 0.42~1.41, P=0.39; infection complications: RR=0.77, 95%CI 0.45~1.30, P=0.39; digestive complications: RR=1.26, 95%CI 0.73~2.16, P=0.41; stopping nasogastric proportion: RR=0.66, 95%CI 0.10~4.10, P=0.65; MODS rate: RR=0.98, 95%CI 0.71~1.35, P=0.90; the percentage of energy balance: RR=1.00, 95%CI 0.97~1.03, P=0.39 and the average length of hospital stay: RR=0.98, 95%CI 0.71~1.35, P=0.90). Conclusions NG feeding was safe and effective, which was comparable with NJ feeding. NG feeding was more convenient with a higher clinical value. Key words: Pancreatitis, acute necrotizing; Enteral nutrition; Self tolerance; Intubation, gastrointestinal