Abstract
Objective To assess the association of 5-hydroxytryptamine 2A (5-HT2A) receptor gene polymorphism with schizophrenia by Meta analysis. Methods Literatures on the relationship between 5-HT2A receptor gene polymorphism T102C and the Chinese schizophrenia in EMBASE, PubMed, CBM, CNKI and Wanfang Med Online were taken as research objects.Screening the relevant data according to the included and excluded standard , then, Software of RevMan 5.0 was employed to do Meta analysis. Meanwhile, we inspect the literatures publication bias. Results Twelve literatures were included, collecting 4 728 individuals , enrolling 2 135 for the schizophrenia group and 2 593 for the control group.The research conforms to Hardy Weinberg equilibrium (all P>0.05). The Meta analysis results showed that there was no significant association between 5-HT2A receptor gene polymorphism and schizophrenia including the allele model, recessive model and codominant model genotypes(all P>0.05). The results of Dominant genetic model I2=45% with moderate heterogeneity, but we used subgroup analysis to remove the author Ni’s data , there were significant difference analysis (I2=9%, Z=2.01, P<0.05). Conclusions 5-HT2A receptor gene T102C site C allele is recessive genes, CC may be a healing factor, there needs evidence-based study provides further evidence. Key words: Schizophrenia; 5-HT2A; T102C; Meta analysis
Published Version
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