Meta-analysis on the association between rs11868035, rs823144, rs3851179 and Parkinson's disease

Abstract

ObjectivesTo determine whether the SNPs rs11868035, rs823144 and rs3851179 associate with PD susceptibility significantly. MethodsA meta-analysis on the effect size of rs11868035, rs823144, rs3851179 on PD risk was conducted. The pooled ORs and 95% CIs with dominant, recessive, and allele models were calculated to examine the association effects. ResultsThe meta-analysis involves 7786 patients with 33,581 controls, 1480 patients with 1453 controls, and 1160 patients with 1856 controls for the three SNPs respectively. The overall ORs (95% CI) in allele model for the three SNPs are 1.0073 (0.7170, 1.4152), 1.2957 (1.1539, 1.4549) and 1.0839 (0.8147, 1.4421), respectively. The major allele in rs11868035 polymorphism among Chinese and Western population is completely opposite (G for Western and A for Chinese). ConclusionsMeta-analysis supports a significant association between RAB7L1 rs823144 and PD risk but indicates no significant association of SREBF1 rs11868035 or PICALM rs3851179 with PD susceptibility.