Abstract
Objective To evaluate the prognostic significance of HER2-neu overexpression in gastric cancer.Methods Investigations between HER2-neu status and survival were identified by published studies.Pooled hazard ratio(HR) and its 95% confidence interval(95%CI) were calculated to evaluate the risk of disease.Results A total of 20 studies were analyzed by Meta-analysis method,including cumulative 4 398 cases.Pooling data from 16 studies of univariate analysis showed worse survival of patients with HER2-neu(+)(pooled HR=1.57,95%CI 1.30~1.90),and maintained in 5 studies of multivariate analysis(pooled HR=1.30,95%CI 1.09~1.52).The analysis for heterogeneity(Q statistic test) for 16 studies of univariate analysis showed they had heterogeneity(Q=27.48,P=0.025),but for 5 studies of multivariate analysis showed little heterogeneity(Q=4.03,P=0.401).Conclusion HER2-neu overexpression is a worse and independent parameter for overall survival of gastric cancer.
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