Abstract
Polymorphisms of the Taq I gene have been associated with prostate cancer risk. We applied a fixed-effects model to combine odds ratios (ORs) and 95% confidence intervals (95% CI). The Egger's test was carried out to evaluate potential publication bias. A total of 10 case-control studies enrolling 1,141 prostate cancer patients and 1,685 controls were included in this meta-analysis. Compared with the T allele, the OR for the C allele was 0.81 (0.70-0.94). The ORs for CT and CC+CT genotypes were 0.86 (0.74-1.01) and 0.84 (0.73-0.97) compared to wide type genotype (homozygote TT). The present meta-analysis suggests that the TF gene Taq I polymorphism may reduce the prostate cancer risk in Asian populations.
Highlights
Prostate cancer is one of the most common malignancies which harm men’s health in United States and Europe; it is the second largest tumor causing male deaths
Inclusion and exclusion criteria The inclusion criteria are as followings: 1) the study is based on analysis of the relationship of vitamin D receptor (VDR) gene TaqI polymorphism and genetic susceptibility to prostate cancer; 2) case-control study; 3) genotype frequency distribution; 4) age matching between treatment group and control group; the literature must be full-text
Basic information Through literature retrieval, we found 27 literatures were about the VDR gene TaqI polymorphism and genetic susceptibility to prostate cancer
Summary
Prostate cancer is one of the most common malignancies which harm men’s health in United States and Europe; it is the second largest tumor causing male deaths. Results: A total of 10 case-control studies enrolling 1,141 prostate cancer patients and 1,685 controls were included in this meta-analysis.
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