Abstract

Objective: To evaluate the efficacy and safety of Xiyanping injection in the treatment of autumnal diarrhea in children with meta analysis.Methods: Related literature about randomized control trials in the treatment of autumnal diarrhea in children with Xiyanping injection published during 1989-2010 were collected from Chinese National Knowledge Infrastructure(CNKI),VIP database and Wanfang database,and evaluations were made by two reviewers independently.The data were statistically analyzed by difference examination,meta and funnel plot analysis.Results: Twenty-two researches met the accepting criteria and their methodological quality was all grade C.Compared with the control group,Xiyanping injection is more effective to autumnal diarrhea in children [odds ratio(OR) 4.95,95% confidence interval(CI,3.84,6.39),P0.000 01],shorter onset time of antifebrile effect[standard mean difference(SMD)-0.72,95% CI(-0.86,-0.57),P0.000 01] and faster antidiarrheal effect[weighted mean difference(WMD)-1.41,95%CI(-1.81,-1.00),P0.000 01].Conclusion: Xiyanping injection is effective in the treatment of autumnal diarrhea in children.However,the defect of poor literature quality and publication bias can't be excluded.

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