Abstract
ObjectiveThis study presents a systematic meta-analysis of the correlation between Helicobacter pylori (H. pylori) infection and autoimmune thyroid diseases (AITD).Materials and MethodsFifteen articles including 3,046 cases were selected (1,716 observational and 1,330 control cases). These data were analyzed using Stata12.0 meta-analysis software.ResultsH. pylori infection was positively correlated with the occurrence of AITD (OR = 2.25, 95% CI: 1.72–2.93). Infection with H. pylori strains positive for the cytotoxin-associated gene A (CagA) were positively correlated with AITD (OR = 1.99, 95% CI: 1.07–3.70). There was no significant difference between infections detected using enzyme-linked immunosorbent assay (ELISA) and other methods (χ2 = 2.151, p = 0.143). Patients with Grave’s disease (GD) and Hashimoto’s thyroiditis (HT) were more susceptible to H. pylori infection (GD: OR = 2.78, 95% CI: 1.68–4.61; HT: OR = 2.16, 95% CI: 1.44–3.23), while the rate of H. pylori infection did not differ between GD and HT (χ2 = 3.113, p = 0.078).ConclusionsH. pylori infection correlated with GD and HT, and the eradication of H. pylori infection could reduce thyroid autoantibodies.
Highlights
Autoimmune thyroid diseases are familial autoimmune disorders that are more common in women than men
H. pylori infection was positively correlated with the occurrence of autoimmune thyroid diseases (AITD) (OR = 2.25, 95% confidence interval (CI): 1.72–2.93)
Infection with H. pylori strains positive for the cytotoxin-associated gene A (CagA) were positively correlated with AITD (OR = 1.99, 95% CI: 1.07–3.70)
Summary
Autoimmune thyroid diseases are familial autoimmune disorders that are more common in women than men. Other typical hallmarks of these diseases are thyroid autoantibodies such as thyrotropin receptor antibody (TRAb), anti-thyroglobulin antibody (TGAb), and antithyroperoxidase antibody (TPOAb) [2]. The production of these autoantibodies can be attributed to both environmental and genetic factors [3]. In 2013, Shi et al [15] systematically evaluated 7 studies including 862 patients, observing that H. pylori infection was associated with the development of AITD in patients with GD but not HT. In this systematic meta-analysis, we further investigated the association between H. pylori infection and AITD
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