Meta-Analysis of the Association Study between Allergic Rhinitis and HLA-II Gene (DQB1) in Northern China.

Jie Wang

doi:10.1155/2021/4356770

Abstract

Objective To explore the association between allergic rhinitis and HLA-II gene (DQB1) in the Chinese population. Methods The literature studies related to allergic rhinitis and HLA-II gene (DQB1) in the Chinese population were searched, and those that did not meet the requirements were excluded. The consistency was checked by using RevMan 4.1 software. Results The HLA-II gene (DQB1) may be a risk gene for patients with allergic rhinitis in Northern China (P < 0.01). Conclusion Allergic rhinitis in China was associated with the HLA-II gene (DQB1).

Highlights

Allergic rhinitis (AR) is a complex disease with a high incidence. e factors leading to the disease are very complex
HLA is located in the 6p21.3 region of the short arm of human chromosome 6, with a total length of about 3600–4000 kb
It is divided into HLA-I, II, and III genes, most of which are related to the immune response

Summary

Introduction

Allergic rhinitis (AR) is a complex disease with a high incidence. e factors leading to the disease are very complex. Allergic rhinitis (AR) is a complex disease with a high incidence. Many scholars believe that unbalanced T helper cell 1 ( 1)/ 2 immune response and elevated levels of immunoglobulin E (IgE) to inhaled allergens are important pathogenesis [3]. Studies show that there are many pathogenic factors such as environment and genes. E meta-analysis of the disease shows that the HLA-DQB1 gene is related to specific IgE-mediated allergic diseases. Other scholars [5,6,7,8,9] have confirmed the correlation between HLA-DQB1 gene polymorphisms and allergic diseases. There are many members of the HLA allele family, which are quite complex. e significant linkage disequilibrium and dominant inheritance characteristics of genes make it difficult to explore. is article explores the correlation between HLA genes and diseases [10]

Materials and Methods

Control group

Findings

Discussion