Abstract
ObjectiveTo investigate the association between common transforming growth factor beta (TGF-β) single nucleotide polymorphisms (SNP) and significant complications of coronary heart disease (CHD).MethodWe performed a meta-analysis of published case-control studies assessing the association of TGF-β SNPs with a range of CHD complications. A random effects model was used to calculate odds ratios and confidence intervals. Analyses were conducted for additive, dominant and recessive modes of inheritance.ResultsSix studies involving 5535 cases and 2970 controls examining the association of common SNPs in TGF-β1 with CHD were identified. Applying a dominant model of inheritance, three TGF-β1 SNPs were significantly associated with CHD complications: The T alleles of rs1800469 (OR = 1.125, 95% CI 1.016–1.247, p = 0.031) and rs1800470 (OR = 1.146, 95% CI 1.026–1.279, p = 0.021); and the C allele of rs1800471 (OR = 1.207, 95% CI 1.037–1.406, p = 0.021).ConclusionThis meta-analysis suggests that common genetic polymorphisms in TGF-β1 are associated with complications of CHD.
Highlights
Coronary heart disease (CHD) is the leading cause of mortality in the western world
Six studies involving 5535 cases and 2970 controls examining the association of common single nucleotide polymorphisms (SNP) in TGF-b1 with CHD were identified
Applying a dominant model of inheritance, three TGF-b1 SNPs were significantly associated with CHD complications: The T alleles of rs1800469 (OR = 1.125, 95% CI 1.016–1.247, p = 0.031) and rs1800470 (OR = 1.146, 95% CI 1.026–1.279, p = 0.021); and the C allele of rs1800471 (OR = 1.207, 95% CI 1.037–1.406, p = 0.021)
Summary
Coronary heart disease (CHD) is the leading cause of mortality in the western world. [1] Early stage CHD is asymptomatic, but advanced disease is associated with severe complications including myocardial infarction, heart failure, unstable angina and sudden cardiac arrest. [3] The genetic mechanisms underlying CHD predisposition are poorly understood despite recent findings from genome-wide association studies (GWAS) (discussed in detail by Patel et al (2011)). Data from independent gene studies suggest a putative role for TGF-b signalling in CHD. [8,9] Some but not all studies suggest a positive association between CHD and several SNPs within genes encoding TGF-b cytokines.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
