Abstract
Studies have shown that the scavenger receptor class B type 1 (SCARB1) rs5888 polymorphism impacts fasting blood lipid levels differently in men and women. A meta-analysis and statistical tests was therefore performed to determine the relationship between the rs5888 polymorphism and lipid levels in men and women. Twelve studies with 12,147 subjects were selected for this study. In a dominant model, the CT+TT genotype group had lower triglyceride levels than the CC group in men (standardized mean difference (SMD): −0.11; 95% confidence interval (CI): −0.21 to −0.02; P = 0.016; I2 = 51.5%). No statistical differences were detected in women. Subgroup analysis of different racial groups revealed significant correlation between the SCARB1 rs5888 polymorphism and higher high-density lipoprotein cholesterol (HDL-C) levels (SMD: 0.15; 95% CI: 0.08 to 0.21; P ≤ 0.001; I2 = 0%) and lower triglyceride levels (SMD: −0.16; 95% CI: −0.26 to −0.04; P = 0.013; I2 = 60.6%) in non-Asian men. No evidence of heterogeneity was observed when eliminating outlier studies, and no publication bias was detected. This meta-analysis suggests the SCARB1 rs5888 polymorphism is associated with higher HDL-C and lower triglyceride levels in non-Asian men.
Highlights
Cardiovascular disease (CVD) is the leading cause of death in developed and many developing countries [1]
Various candidate genes have been reported as predisposing factors for dyslipidemia, including those involved in lipid transport and metabolism [3]
We present here the first metaanalysis to investigate the association between scavenger receptor class B type 1 (SCARB1) polymorphisms, sex, and lipid levels
Summary
Cardiovascular disease (CVD) is the leading cause of death in developed and many developing countries [1]. Risk factors such as hypertension, dyslipidemia, and adiposity may contribute to the development of CVD. Dyslipidemia is characterized by abnormal blood lipid levels, such as increased low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and total cholesterol (TC) and decreased high-density lipoprotein cholesterol (HDL-C) [2]. Dyslipidemia is a risk factor for the development of CVD and an important topic of research [2]. Chromosomal regions and specific genes such as cholesterol ester transfer protein (CETP) and scavenger receptor class B type 1 (SCARB1) have been proposed to be associated with blood lipid levels [3]. Analysis of nucleotide polymorphisms is a useful tool to better understand differences in lipid levels
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