Abstract
There were a number of studies performed to assess the association between NQO1 Pro187Ser polymorphism and colorectal cancer risk in Asians, but no consensus was available up to now. We conducted a meta-analysis to assess the association between NQO1 Pro187Ser polymorphism and colorectal cancer risk in Asians. Case-control studies investigating the association between NQO1 Pro187Ser polymorphism and colorectal cancer risk in Asians were searched in Pubmed and Wanfang databases. Pooled odds ratio (OR) and 95% confidence interval (95% CI) was calculated. Finally, seven studies involving a total of 2,051 cases and 2,798 controls met the inclusion criteria and were included into the meta-analysis. Overall, there was an obvious association between NQO1 Pro187Ser polymorphism and colorectal cancer risk in Asians (Ser versus Pro: OR = 1.42, 95% CI 1.08-1.87, P = 0.013; SerSer versus ProPro: OR = 1.86, 95% CI 1.08-3.19, P = 0.024; SerSer/ProSer versus ProPro: OR = 1.61, 95% CI 1.10-2.35, P = 0.014; SerSer versus ProPro/ProSer: OR = 1.46, 95% CI 1.02-2.10, P = 0.041). There was low risk of publication bias in the meta-analysis. This meta-analysis suggests that there is an obvious association between NQO1 Pro187Ser polymorphism and colorectal cancer risk in Asians.
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