Abstract
Genetic variants are linked to vitiligo and associated autoimmune diseases. We performed a meta-analysis to evaluate the effects of the rs12150220, rs2670660, and rs6502867 polymorphisms within the human NLR Family Pyrin Domain Containing 1 (NLRP1) gene. We initially identified 1,306 candidate articles through literature searches of Pubmed, WOS, Embase, CNKI, WANFANGI, Ovid, Scopus, and Cochrane in July 2017. After strict screening, we included 19 eligible case-control studies, and analyzed the data using Stata/SE 12.0 software. No difference between vitiligo cases and controls was detected for NLRP1 rs12150220, rs2670660, or rs6502867 under most genetic models [Passociation (P value of association test) > 0.05). With regard to vitiligo-associated autoimmune diseases, like Addison's disease, type 1 diabetes, or systemic lupus erythematosus, a decreased risk was detected for rs12150220 in the Caucasian subgroup under all models [Passociation < 0.05, odds ratio (OR) < 1]. No relationships were observed for other polymorphisms, including rs2670660, rs6502867, and the “A-A, G-T, G-A, A-T” haplotypes of rs2670660/rs12150220 (Passociation > 0.05). This meta-analysis demonstrates that within the Caucasian population, the NLRP1 rs12150220 polymorphism may correlate with a decreased risk of vitiligo-associated autoimmune diseases, especially autoimmune Addison's disease, type 1 diabetes, or systemic lupus erythematosus.
Highlights
Vitiligo is a complicated autoimmune disorder characterized by skin depigmentation from progressively abnormal melanocytes [1, 2]
1,306 candidate articles were retrieved from eight online databases: Pubmed (n = 97), Web of Science (WOS, n = 274), ExcerptaMedica Database (Embase, n = 70), China National Knowledge Infrastructure (CNKI, N = 9), WANFANG (n = 32), Ovid (n = 345), Scopus (n = 474), and Cochrane (n = 5). 459 duplicate articles were removed. 820 articles were excluded after further screening
Those same polymorphisms yield contradictory conclusions on their correlation with vitiligo-associated autoimmune diseases [4, 24, 25, 31, 32]. Due to these disparate results, we performed a comprehensive meta-analysis to explore the association between NLRP1 single nucleotide polymorphisms (SNPs) and vitiligo susceptibility, as well as vitiligo-associated autoimmune diseases
Summary
Vitiligo is a complicated autoimmune disorder characterized by skin depigmentation from progressively abnormal melanocytes [1, 2]. Predisposition to vitiligo and its associated autoimmune diseases may be related to single nucleotide polymorphisms (SNPs) of genes, such as rs12150220, rs2670660, rs6502867, and rs8182352 of the NLRP1 gene on chromosome 17p13.2, which is named NALP1 (NACHT, LRR, and PYD Domains-Containing Protein 1) [8,9,10,11,12]. NLRP1 protein is a member of the nucleotide oligomerization domain-like receptors (NLRs) family and regulates inflammasome activation, cellular apoptosis, innate immune system [13, 14], and some inflammatory disorders or autoimmune diseases [15]. The possible role of s2670660/rs12150220 haplotypes was analyzed
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