Meta-analysis of self-adhesive soft silicone film dressings on preventing and treating radioactive skin lesion

Abstract

Objective To systematically assess the effects of self-adhesive soft silicone film dressings on preventing and treating radioactive skin lesion. Methods Randomized controlled trials (RCT) about self-adhesive soft silicone film dressings on preventing and treating radioactive skin lesion were retrieved from PubMed, Web of Science, Cochrane Library, Embase, CNKI, VIP and Wanfang databases, and RevMan 5.3 was used for Meta-analysis of the trials which met the inclusion criteria. Results Totally 10 RCTs were included, with a sample size of 1 231 cases. Meta-analysis revealed that self-adhesive soft silicone film dressings could reducethe incidence of GradeⅡ or above radiodermatitis (OR=0.14, 95%CI 0.08-0.25, P<0.01) , shorten the occurrence time of radiodermatitis within the field of radiotherapy (OR=0.07, 95%CI 0.02-0.32, P<0.01) , and reduce subjective and objective symptom scores of radiodermatitis (Radiation-induced Skin Reaction Assessment Scale, RISRAS) (MD=-3.33, 95%CI-5.96--0.70, P<0.05) . Conclusions Self-adhesive soft silicone film dressings applied on the cutaneous surface within the field of radiotherapy can reduce the severity of radiodermatitis, shorten the occurrence time of radioactive skin lesion within the field of radiotherapy, and effectively ameliorate cutaneous discomfort within the field of radiotherapy and the effects of radiotherapy-induced skin reaction on daily activities. Key words: Radiodermatitis; Self-adhesive soft silicone film dressings; Skin lesion; Malignant neoplasms; Meta-analysis