Meta-analysis of randomized controlled trials comparing selective laser trabeculoplasty with prostaglandin analogue in the primary treatment of open-angle glaucoma or ocular hypertention

Abstract

To compare the efficacy of selective laser trabeculoplasty (SLT) versus prostaglandinanalogue (PGA) in the treatment of open angle glaucoma (OAG) and ocular hypertension (OHT). Literature analysis.Systematic review of randomized controlled trials comparing SLT versus PGA, identified by searching literatures including Medline (January, 1966-December, 2012), EMBASE Reviews (January, 1974-December, 2012) OVID Evidence-Based Medicine Reviews (January, 1966-December, 2012), Chinese BioMedical Literature Database SinoMed (January, 1966-December, 2012), and CNKI (January, 1999-December, 2012). RevMan 5.0 was used to do meta-analysis. Three publications reporting 3 trials, 161 participants (231 eyes) with OHT or OAG were included for meta-analysis.IOP reduction favored PGA group, weighted mean difference (WMD) = -0.85[1 mmHg = 0.133 kPa; 95% confidence interval (CI) (-1.43 to -0.27), no significant heterogeneity present (P = 0.82, I² = 0%)].Success rates are equal in two groups [OR = 0.70, 95%CI = (0.49 to 1.19) , no significant heterogeneity present (P = 0.58, I² = 0%)]. Eyes underwent additional antiglaumatous interventions favored SLT group, OR = 1.11 [95%CI = (0.60 to 2.06), significant heterogeneity present, (P = 0.08, I² = 61%)]. As primary therapy of OAG or OHT, SLT is no more effective than PGA in success rate. IOP reduction affected by SLT is not effective than PGA. Compared with PGA, SLT can reduce the use of anti-glaucoma medications.