Meta-Analysis of miR-146a Polymorphisms Association with Coronary Artery Diseases and Ischemic Stroke.

Mei-Hua Bao,Jie Zeng,Guang-Yi Li,Yan Xiao,Juan Zhao,Qing-Song Zhang,Huai-Qing Luo,Ji Luo,Jian-Ming Li

doi:10.3390/ijms160714305

Mei-Hua Bao, Jie Zeng + Show 7 more

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https://doi.org/10.3390/ijms160714305

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Abstract

Coronary artery disease (CAD) and ischemic stroke (IS) are manifestations of atherosclerosis, with a high death rate. miR-146a is a microRNA that participates in the progress of CAD and IS. A single nucleotide polymorphism (SNP) in the precursor of miR-146a, rs2910164, was found to be associated with the risks of CAD and IS. However, the results were inconsistent and inconclusive. A meta-analysis was performed to assess the relationship of rs2910164 and CAD as well as IS susceptibility. The database Pubmed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Chinese National Knowledge Infrastructure (CNKI), and Chinese Biomedical Literature Database (CBM) were searched for related studies. Crude odds ratios with 95% confidence intervals were used to investigate the strength of the association by random- or fixed-effect model. A total of eight studies, with 3138 cases and 3097 controls were identified for the meta-analysis. The results shows that rs2910164 is associated with the risk of CAD significantly in allelic model (OR = 0.86), homozygous model (OR = 0.70), heterozygous model (OR = 0.80) and dominant model (OR = 0.76). The subjects carrying the GG genotype, GG + GC genotype or G allele are at lower risks of CAD. For the susceptibility of IS, there are no significant associations between rs2910164 and total studies. However, in subgroup analysis by sample size and ethnicity, the GG, GG + GC and G allele of rs2910164 are found to be associated with higher risks of IS in large sample size group and in Koreans, under homozygous and dominant models. In conclusion, the current meta-analysis suggests lower risks of CAD for GG, GG + GC genotype and G allele of rs2910164, while rs2910164 is not associated with the risk of IS. Thus rs2910164 might be recommended as a predictor for susceptibility of CAD, but not IS.

Highlights

Cardiovascular diseases are the major cause of death and disability worldwide
For Coronary artery disease (CAD), significantly decreased risks were found to be associated with rs2910164 under all genetic models, allelic model (OR = 0.86, 95% confidence interval (CI) = 0.77–0.96, p = 0.01), homozygous model
The main findings of our meta-analysis show that rs2910164 is associated with the risk of CAD

Summary

Introduction

Cardiovascular diseases are the major cause of death and disability worldwide. According to the World Health Organization report in 2011, more than 17 million people died of cardiovascular diseases. Coronary artery disease (CAD) is characterized by occlusive epicardial coronary artery stenosis. Ischemic stroke (IS) is a major kind of stroke, which causes a high death rate and adult disability in the world. According to the report of Liu, the annual stroke mortality rate was 120–180 per 100,000 in China [1]. In the United States, stroke ranks as the third leading cause of death [2]. IS has exceeded heart diseases to become the most frequent cause of death. IS and CAD are principal clinical manifestations of atherosclerosis, and have caused a huge burden for society. Previous studies demonstrated that single nucleotide polymorphisms (SNPs) were associated with the risks of CAD and IS [3,4]

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