Meta-analysis of efficacy and safety of cefepime

Abstract

In this issue of The Journal, Adderson et al report a systematic review and meta-analysis of randomized controlled trials of the fourth generation cephalosporin agent, cefepime, in children following the Food and Drug Administration's review of the report of increased all-cause mortality with cefepime monotherapy versus comparator in a meta-analysis predominantly involving adults. The meta-analysis of pediatric patients by Adderson et al does not support excess all-cause mortality or clinical failure associated with cefepime therapy in trials.