Abstract
Abstract Several independent studies been conducted to understand the genetic and environmental factors influencing the cause of atopic dermatitis, which is an inflammatory skin disorder. To leverage the power of combining the studies we downloaded seven publicly available datasets on atopic dermatitis from ImmPort data portal (https://immport.niaid.nih.gov/). These studies include wide range of molecular and cellular measurements like ELISA, flow and complete blood count (CBC) across multiple cohort and various sample types. We have taken the meta-analysis approach to understand the factors influencing the disease phenotype by integrating the datasets measured under different conditions to find the associations between independent and combined effects. The molecular and cellular measurements were normalized such that data is comparable across studies. We have found a strong association of certain inflammatory cytokines in atopic dermatitis patients under specific conditions, and perturbations in certain cell types of these patients. We also evaluate the influence of gender, age and vaccine response in atopic dermatitis patients with respect to healthy controls.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
