Abstract
Meta-analysis of Association between Helicobacter pylori Infection and Epilepsy
Highlights
Helicobacter pylori (H. pylori) is a gram-negative bacterium and mainly associated with chronic gastritis, peptic ulcer disease, gastric cancer and gastric mucosa-associated lymphoid tissue lymphoma [1,2]
The prevalence of H. pylori infection in patients with epilepsy was higher than that in control groups. (46.98% vs. 26.34%, odds ratio (OR) = 2.58, 95% confidence interval (CI): 1.15-5.82, P = 0.02) (Figure 2)
The association between epilepsy and H. pylori infection is controversial [10,11,12,13,14,15]. In this meta-analysis we provide an overview of the relationship between H. pylori positiveity and epilepsy with a total of 418 subjects from four eligible studies
Summary
Helicobacter pylori (H. pylori) is a gram-negative bacterium and mainly associated with chronic gastritis, peptic ulcer disease, gastric cancer and gastric mucosa-associated lymphoid tissue lymphoma [1,2]. Some reports have discerned a relationship between H. pylori infection and extra-gastrointestinal diseases such as cirrhosis, pancreatic cancer, coronary heart disease, stroke, migraine, Alzheimer’s disease and Multiple sclerosis [3,4,5,6,7,8]. As these results remain controversial, the interactions between H. pylori and humans are suggested to be extremely sophisticated [9]. To obtain a more comprehensive estimate of the association we conducted a meta-analysis to determine the prevalence of H. pylori infection in patients with epilepsy and controls
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