Abstract
背景与目的上皮细胞钙粘蛋白E-cadherin在维持上皮的极性和结构完整性等方面起着重要作用，并与肿瘤的发生、浸润和转移密切相关。E-cadherin基因启动子区甲基化与肿瘤发生发展的关系一直是研究的热点，而该基因甲基化与肺癌易感性的关系尚存在争议。本研究旨在通过meta分析的方法更好地探讨E-cadherin基因启动子区甲基化与肺癌易感性之间的关系。方法利用PubMed/MedLine和EMBASE数据库检索2013年3月以前的相关文献，由两位研究人员做独立文献筛选和资料提取，并交叉审核。使用优势比（odds ratio, OR）及95%置信区间（confidence interval, CI）衡量E-cadherin基因启动子区甲基化与肺癌易感性关系的强弱。结果根据检索条件，共有13项研究（共涉及1, 288例实验样本）被纳入当前的meta分析。分析结果显示E-cadherin基因启动子区甲基化明显增加了肺癌发生风险（OR=4.04, 95%CI: 2.00-8.13, P < 0.001），且这种相关性同时存在于亚洲人群和高加索人群（OR=3.28, 95%CI: 1.20-8.92; OR=5.72, 95%CI: 2.40-13.62）。结论E-cadherin基因启动子区甲基化与肺癌易感性之间存在明显相关性。
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