Abstract
To conduct a systematic review of studies assessing the association of anti-GP210 antibody and anti-SP100 antibody with diagnosis of primary biliary cirrhosis (PBC) using meta-analysis. Five research literature databases, including the Cochrane Library, MEDLINE, VIP, CNKI and WanFang, were searched for studies of anti-GP210 antibody and anti-SP100 antibody in diagnosis of PBC. Meta-disc statistical software was used for analysis. The meta-analysis included a total of 25 studies on anti-GP210 antibody and 21 studies on anti-SP100 antibody. The diagnostic odds ratio, sensitivity, and specificity of anti-GP210 antibody for diagnosis of PBC were 24.854 (11.957-51.660), 0.272 (0.257-0.288), and 0.985 (0.982-0.988), respectively, and for anti-SP100 antibody they were 9.133 (4.739-17.600), 0.231 (0.213-0.249), and 0.977 (0.973-0.981), respectively. Both anti-GP210 antibody and anti-SP100 antibody show high specificity but low sensitivity in diagnosis of PBC.
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