Messengers from the synapses to the nucleus (MSNs) that establish late phase of long-term potentiation (LTP) and long-term memory

Abstract

The late stage of long-term potentiation (LTP) and long-term memory is believed to be largely governed by altered gene expression for its generation and maintenance, while the early stages of LTP and memory are controlled mainly by the phosphorylation-dephosphorylation of the synaptic proteins. For the altered gene expression, synaptic information must be transmitted from the synaptic sites to the nucleus. This article describes the presence of specific messenger molecules that transmit synaptic information to the nucleus; these molecules are referred to as MSNs (Messengers from Synapse to the Nucleus). In addition, recent studies have indicated that certain transcription factors localize at postsynaptic sites as well as the nucleus, and may function as MSNs.