Abstract
The search for new efficient photosensitizers in photodynamic therapy (PDT) points to improve photophysical properties like absorption in the red region and singlet oxygen quantum yield as well as to control the localization of the sensitizer within the tumor cell. Depending on their physicochemical properties and their uptake mechanism, photosensitizers can reach different intracellular concentrations and localize in different subcellular compartments . Moreover, the preferential localization of a photosensitizer in target organelles, such as mitochondria or Golgi apparatus, can determine the cell death mechanism after PDT. The intracellular uptake was found to be closely related to the molecular structure of sensitizers and its subcellular trafficking in our study. Furthermore, Our result also revealed that more ROS were detected according to the increased incubation time which resulted in more cellular uptake of photosesitizers .
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