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Abstract
Mesoporous phosphate-based glasses have great potential as biomedical materials being able to simultaneously induce tissue regeneration and controlled release of therapeutic molecules. In the present study, a series of mesoporous phosphate-based glasses in the P2O5-CaO-Na2O system, doped with 1, 3, and 5 mol% of Sr2+, were prepared using the sol-gel method combined with supramolecular templating. A sample without strontium addition was prepared for comparison. The non-ionic triblock copolymer EO20PO70EO20 (P123) was used as a templating agent. Scanning electron microscopy (SEM) images revealed that all synthesized glasses have an extended porous structure. This was confirmed by N2 adsorption-desorption analysis at 77 K that shows a porosity typical of mesoporous materials. 31P magic angle spinning nuclear magnetic resonance (31P MAS-NMR) and Fourier transform infrared (FTIR) spectroscopies have shown that the glasses are mainly formed by Q1 and Q2 phosphate groups. Degradation of the glasses in deionized water assessed over a 7-day period shows that phosphate, Ca2+, Na+, and Sr2+ ions can be released in a controlled manner over time. In particular, a direct correlation between strontium content and degradation rate was observed. This study shows that Sr-doped mesoporous phosphate-based glasses have great potential in bone tissue regeneration as materials for controlled delivery of therapeutic ions.
Highlights
In recent years, mesoporous glasses have gained increased attention in the field of functional biomaterials (Baino et al, 2016)
Simulated body fluid (SBF) or phosphate buffered saline (PBS) as alternative media solutions were not used as they contain Ca2+, Na+ and phosphate anions that would have interfered with the quantification of the small amount of the same ions released from the glasses
The composition of the glasses was determined via chemical analysis carried out using Scanning electron microscopy (SEM) equipped with an EDX detector
Summary
Mesoporous glasses have gained increased attention in the field of functional biomaterials (Baino et al, 2016). In PGs, strontium has been incorporated only into MQ prepared systems (Abou Neel et al, 2009a; Al Qaysi et al, 2015; Sriranganathan et al, 2016) These studies confirmed the potential applications of Sr-doped PGs as effective vehicles to deliver Sr2+ to bone cells (Abou Neel et al, 2009a; Lakhkar et al, 2011). Here we presented for the first time a study on the sol-gel synthesis and characterization of strontium doped mesoporous phosphate-based glasses and the effect of strontium addition on dissolution properties
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