Abstract
The platinum complex with 2,3-disubstituted-1,4-naphthoquinone was evaluated as a potential new anti-ulcer drug, due to its inhibition effect on urease. This complex was supported on the obtained silica and amino-mesoporous silica with typical structure and texture. Presence of the amine group and platinum complex on the silica materials was confirmed by FT-IR measurements. Determination of the urease activity was made with Nessler reagent. The obtained results evidenced a high inhibitor effect on urease activity. This effect was diminished after platinum complex immobilization on mesoporous silica. Although the inhibitor effect of platinum complex on urease activity decreased, it was evidenced its stability after immobilization on silica mesoporous supports. This is the consequence of a longer releasing time for platinum complex immobilized on mesoporous silica, more significant for sample supported on amino-mesoporous silica
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