Abstract
Amidoxime (AMI), an amphoteric functional ligand, mesoporous silica material (SBA-15@AMI NPs) was prepared and the pH-responsive drug release behavior was examined using Dox as model anticancer drug. Further, the cytocompatibility and the cell uptake results revealed that SBA-15@AMI NPs could be applied as pH-responsive drug delivery applications in cancer therapy. • Developing pH- responsive drug delivery system is attracted a great concern. • An amphoteric ligand functionalized SBA-15@AMI NPs for pH-responsive drug delivery system has been proposed. • The SBA-15@AMI NPs is applicable for delivery of anticancer drugs in cancer therapy. Amidoxime (AMI) functionalized mesoporous silica material (SBA-15@AMI NPs) was synthesized by surface modification approaches. This method allows for the creation of a higher concentration of amidoxime ligand groups to the SBA-15's surface without affecting the morphology. The synthesized SBA-15@AMI NPs were verified using a range of instrumental characterizations. Further, the drug loading and pH-responsive release behavior of the SBA-15@AMI NPs were examined using Dox as model anticancer drug. The biocompatibility and cellular uptake behavior was studied using MCF-7 cell line. Overall, the prepared SBA-15@AMI NPs could be applied as pH-responsive drug delivery applications in cancer therapy.
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