Abstract
Biosafety of mesoporous silica particles (MSP) is still controversial since various parameters such as chemical composition, morphology, and entrance route may exert various mechanisms in cells and organs. This report exhibits the first findings of the biological actions induced by MSP loaded with 1,4-naphthoquinone evaluated in a respiratory ex vivo model of isolated trachea ring, suggesting that this complex in cumulative concentrations induced transient contractions in that airway conduit acetylcholine-like profile associated to nitric oxide (NO) production.
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