Abstract
Abstract A novel photo-thermal and redox-responsive drug delivery carrier was developed by capping mesoporous silica nanoparticles (MSNs) with graphene quantum dots (GQDs). The disulfide bonds were introduced by amidation reaction between cystine and amino functionalized MSNs. Rhodamine B (RhB), a red fluorescent dye, was loaded into the mesopores of MSNs as the model drug and GQDs capped on MSNs as gatekeepers could prevent the release of RhB. Transmission electron microscopy (TEM), nitrogen adsorption and desorption analysis, X-ray diffraction (XRD), thermogravimetric (TG) analysis and Fourier transform infrared spectroscopy (FTIR) proved that the nanocomposites MSNs capped with GODs were achieved successfully. The nanocomposites with the size of about 100 nm have excellent photo-thermal property originated from GQDs. Moreover, the nanocomposites were endowed with remarkable redox-responsion to glutathione (GSH) from disulfide bonds, and hence the loaded drugs could release controlably. In this work, we provided an exploration of photo-thermal and redox-responsive drug delivery system and the results proved that this drug delivery system can be considered as a promising candidate for drug delivery and stimuli-responsive release.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
