Abstract
Mesoporous silica (MPS) nanoparticle was prepared as carriers for drug delivery systems by sol–gel method from sodium silicate as inexpensive precursor of silica and Cocamidopropyl betaine (CABP) as template. The silica particles were characterized by SEM, TEM, AFM, XRD, and N2adsorption–desorption isotherms. The results show that the MPS particle in the nanorange (40-80 nm ) with average diameter equal to 62.15 nm has rods particle morphology, specific surface area is 1096.122 m2/g, pore volume 0.900 cm3/g, with average pore diameter 2.902 nm, which can serve as efficient carriers for drugs. The adsorption kinetic of Ciprofloxacin (CIP) drug was studied and the data were analyzed and found to match well with pseudo-first order kinetic model. The CIP drug-loaded mesoporous silica (CIP-mSiO2) nanoparticles has capacity of about 16.3 mg drug/ mg mSiO2 were achieved, and capable of releasing 26% and 98.6% of their drug content after 90 min in water and PBS solution(pH,7.4) respectively. In-vitro controlled release studies of CIP in Simulated Body Fluid were carried out under stirring conditions. A study on release kinetics and mechanism using Koresmeyer-Pepps model, first order kinetic, and kopcha model shows that the Korsmeyer-Peppas and Kopcha models, both conform more closely to the release data.
Highlights
Among the materials which may have widespread potential as drug carriers such as colloidal systems, liposomes, micro emulsion, etc. [1-4], mesoporous silica (MPS) have some engaging properties, for example large pore volume and surface area, narrow pore size range, chemically inert and allowing easier functionalization of their surface [5, 6] which make them an attractive drug carrier and its release.In 2001, MPS was first reported as a drug delivery system and in which they loaded ibuprofen drug into the mesoporous of MPS which exhibited high drug loading capacity and sustained drug release [7]
It is revealed from the images that particles morphology is almost rod type
The foregoing results of this study confirm the synthesis of mesoporous silica nanoparticle as carriers for CIP drug delivery systems by sol–gel method
Summary
Among the materials which may have widespread potential as drug carriers such as colloidal systems, liposomes, micro emulsion, etc. [1-4], mesoporous silica (MPS) have some engaging properties, for example large pore volume and surface area, narrow pore size range, chemically inert and allowing easier functionalization of their surface [5, 6] which make them an attractive drug carrier and its release.In 2001, MPS was first reported as a drug delivery system and in which they loaded ibuprofen drug into the mesoporous of MPS which exhibited high drug loading capacity and sustained drug release [7]. Among the materials which may have widespread potential as drug carriers such as colloidal systems, liposomes, micro emulsion, etc. [1-4], mesoporous silica (MPS) have some engaging properties, for example large pore volume and surface area, narrow pore size range, chemically inert and allowing easier functionalization of their surface [5, 6] which make them an attractive drug carrier and its release. In 2001, MPS was first reported as a drug delivery system and in which they loaded ibuprofen drug into the mesoporous of MPS which exhibited high drug loading capacity and sustained drug release [7]. The controlled release from its carrier has been studied [8]. A novel mesoporous silica nanoparticles as a carrier for Ibuprofen drug was synthesized and the release kinetics was evaluated. The results show that the synthesized carrier exhibited high loading and a very good release rate [9]
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