Abstract
In this work we describe the relationship between surface modification of hexagonally ordered mesoporous silica SBA-15 and loading/release characteristics of nonsteroidal anti-inflammatory drug (NSAID) naproxen. Mesoporous silica (MPS) was modified with 3-aminopropyl, phenyl and cyclohexyl groups by grafting method. Naproxen was adsorbed into pores of the prepared MPS from ethanol solution using a solvent evaporation method. The release of the drug was performed in buffer medium at pH 2 and physiological solution at pH 7.4. Parent MPSs as well as naproxen loaded MPSs were characterized using physicochemical techniques such as nitrogen adsorption/desorption, thermogravimetric analysis (TG), Zeta potential analysis, Fourier transform infrared spectroscopy (FT-IR), and elemental analysis. The amount of naproxen released from the MPSs into the medium was determined by high-performance liquid chromatography (HPLC). It was shown that the adsorption and desorption characteristics of naproxen are dependent on the pH of the solution and the surface functionalization of the host.
Highlights
In the early 1990s, scientists from the Mobile company discovered a highly ordered mesoporous silica MCM-41 (Mobile Composition of Matter) [1]
We have studied eight different SBA-15 mesoporous silica-based samples
The samples were prepared by surface modification of SBA-15 by different ligands and/or subsequent loading with naproxen molecules
Summary
In the early 1990s, scientists from the Mobile company discovered a highly ordered mesoporous silica MCM-41 (Mobile Composition of Matter) [1]. Their discovery started intense research that showed the exceptional properties of mesoporous silica (MPS), such as good biocompatibility, large specific surface area, controllable pore volume and particle size. The properties of mesopores, including their size and volume as well as the surface properties of MPS, can be altered depending on additives used to fabricate silica nanoparticles and/or by a simple change of preparation conditions (temperature, time, pressure, precursor type, concentration, etc.). The unique mesoporous structure of silica facilitates the effective loading of drugs and their subsequent controlled release.
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