Abstract
Abstract In this paper, a pH-/thermal-/NIR multi-responsive drug delivery platform based on hollow hydroxyapatite (H-HAP), poly(N-isopropylacrylamide- co-acrylic acid) (PNA) and gold nanorods (AuNRs) were prepared via electrostatic self-assembly. Thermal-sensitive PNA and near-infrared (NIR) responsive AuNRs were capped on the surface of mesoporous hollow HAP to obstruct the initial burst release of HAP and endow the vehicles with multi-responsive drug delivery properties. Notable pH-/thermal-/NIR multi-responsive drug release properties were clearly observed for H-HAP/PNA/AuNRs hybrid microcapsules. In addition, relatively high DOX release could be found for H-HAP/PNA/AuNRs hybrid microcapsules at pH 4.5 upon NIR laser irradiation, due to the corrosion of H-HAP in acidic media and the synergistically photothermal effect between AuNRs and PNA. This study provides a feasible method to fabricate intelligently controllable hybrid drug carriers, which shows great potential in controllable drug delivery.
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