Mesonephric Adenocarcinoma of Uterine Cervix; A Case Report and Review of the Literature

Fatemeh Nili,Samaneh Salarvand,Hana Saffar,Bita Kalaghchi,Reza Ghalehtaki

doi:10.30699/ijp.2020.125459.2375

Abstract

Mesonephric adenocarcinoma of the uterine cervix is an extremely rare tumor of the female genital tract which derives from the remnants of embryonic mesonephric ducts and its prognosis, diagnosis and treatment is rather challenging. We report a case of a 46-year-old woman with history of abnormal uterine bleeding and an enlarged uterine cervix on physical examination without obvious mass lesion. She was clinically underdiagnosed with cervical myoma and mesonephric hyperplasia. After simple hysterectomy, stage IB2 mesonephric adenocarcinoma was diagnosed. Despite adjuvant chemoradiation, she presented with peritoneal and locoregional recurrence in less than a year. So, in the presence of abnormal bleeding and cervical mass, mesonephric hyperplasia in cervical biopsy specimen should be suspected for adenocarcinoma. Radical hysterectomy and complete staging with or without salpingo-oophorectomy is the mainstay of treatment. Despite all ambiguities, due to the small number of reported cases, the overall prognosis seems to be less favorable than conventional cervical adenocarcinoma.

Highlights

Mesonephric adenocarcinoma of the uterine cervix is an extremely rare tumor of the female genital tract which derives from the remnants of embryonic mesonephric ducts and its prognosis, diagnosis and treatment is rather challenging
Mesonephric adenocarcinoma of the uterine cervix is an extremely rare tumor of the female genital tract which derives from the remnants of embryonic mesonephric (Wolffian) ducts [1]
Mesonephric adenocarcinoma usually shows a mixture of morphologic patterns making the pathologic diagnosis challenging

Summary

Introduction

Mesonephric adenocarcinoma of the uterine cervix is an extremely rare tumor of the female genital tract which derives from the remnants of embryonic mesonephric ducts and its prognosis, diagnosis and treatment is rather challenging. Mesonephric adenocarcinoma of the uterine cervix is an extremely rare tumor of the female genital tract which derives from the remnants of embryonic mesonephric (Wolffian) ducts [1]. These remnants may persist in the broad ligaments or the lateral walls of uterine cervix or vagina, appearing as small groups of glands or tubules. They may transform to benign cysts or hyperplasia and rarely to malignant tumors [2].

Results

Conclusion