Abstract
The effect of hemorrhage and of reinfusion on the mesenteric circulation of dogs was determined. During the control period, the average mesenteric vascular resistance was 0.6 P.R.U., and the average mesenteric plasma volume was 100 ml. Hemorrhagc produced an early reduction in mesenteric plasma volume, averaging 50 per cent, without any accompanying change in mesenteric vascular resistance. As the hemorrhagie period progressed, mesenteric vascular resistance rose to a level 120 per cent above control coincidental with the autoinfusion of blood from the hemorrhagc reservoir. With the elevation in mesenteric vascular resistance, mesenteric plasma volume displayed a slight additional decline. Reinfusion produced only a slight and transient recovery of mesenteric vascular resistance and plasma volume. A comparison of mesenteric vascular resistance changes with those of mesenteric plasma volume indicates that no uniform relationship exists. Similar dissociation was seen between mesenteric plasma volume and portal venous pressure. No evidence of pooling of blood in the mesenteric circulation during the induction and development of normovolemic hemorrhagie shock was observed.
Highlights
Group I consisted of those preparations which displayed a progressive elevation in mesenteric vascular resistance during the late hemorrhage phase, while group II animals exhibited little or no significant change in mesenteric vascular resistance throughout the hemorrhagic period
Hemorrhage produced an early reduction in mesenteric plasma volume, averaging 50 per cent, without any accompanying change in mesenteric vascular resistance
As the hemorrhagic period progressed, mesenteric vascular resistance rose to a level 120 per cent above control coincidental with the autoinfusion of blood from the hemorrhage reservoir
Summary
Mongrel dogs ranging in weight from 12 to 30 Kg. were used. The animals were anesthetizedFrom the Department of Physiology, Indiana University School of Medicine, Indianapolis, Indiana.Supported in part by Research Grants H4O5(JC1Selkurt and H4684-Friedman from the Xational Heart Institute, Xational Institutes of Health, U.S Public Health Service, Washington, D.C.Received for publication December 1, 1960.with pentobarbital (30 mg./Kg.) by means of intravenous injection. The carotid and femoral arteries and the jugular and femoral veins were isolated
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