Abstract

AbstractBone has good innate healing potential but faces increased morbidity, and in extensive bone damage, infections, or in systemic affections, the said potential is delayed (delayed union) and/or even inhibited (non-union). To boost bone regeneration timely and effectively, regenerative medicine is being evaluated. Mesenchymal stem cells (MSCs) along with scaffolds are being evaluated with both in vitro and in vivo studies demonstrating their potential bone-healing properties. In vitro studies mainly focus on their differentiation capacity towards the osteogenic differentiation lineage through culture incorporated growth factors, matrices/scaffolds and/or mechanical factors. In vivo studies (experimental and clinical) demonstrate tissue-engineered constructs employing MSCs as potential candidates to enhance regeneration of bone defects in various kinds of mechano-dynamic models and clinical conditions. MSCs transplantation has mostly been made along with the suitable scaffolds to fill the gap and provide a suitable environment besides maintaining the cells in situ. The current chapter focuses on the bone regenerative potential of MSCs along with the scaffolds in veterinary species.KeywordsBone fractureMesenchymal stem cellOsteoporosisExperimental modelClinical cases

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