Abstract
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women with characteristics of inflammation, hyperandrogenism, and polycystic ovaries. Most available therapies for PCOS aim to regulate the steroidogenesis and decrease ovarian androgen production to enhance fertility. Our previous study shows the ability of human bone marrow mesenchymal stem cells conditioned media (MSC-CM) to inhibit androgen production by human theca-like cell model (H295R cells). Previous studies demonstrated the ability of BMP-2 as a modulator of androgen production and alteration in steroidogenesis pathway enzymes in bovine theca cells.
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