Abstract
In this paper, we report on spatial redistribution of bone marrow mesenchymal stem cells loaded with magnetic nanoparticles under the influence of continuously applied magnetic field. Semiconductor nanoparticles were synthesized by epitaxial growth of a GaN thin layer on magnetic sacrificial core consisting of ZnFe2O4 nanoparticles. Different quantities of nanoparticles were incubated in vitro with mesenchymal stem cells. High density of nanoparticles (50 μg/ml) leads to a decrease in the number of cells during incubation, while the density of nanoparticles as low as 10 μg/ml is enough to drag cells in culture and rearrange them according to the spatial distribution of the magnetic field intensity.
Highlights
Stem cells are defined by their ability to self-renewal and differentiation into more specialized cells, depending on their level of potency [1]
Nanometre-scale thin layers of gallium nitride nanoparticles (GaN) have been grown on sacrificial zinc ferrite (ZnFe2O4) based nanoparticles acquired from Sigma-Aldrich (CAS#12063-19-3)
The high-quality hydride vapor phase epitaxy (HVPE)-grown GaN layer on zinc ferrite nanoparticles is revealed by transmission electron microscopy (TEM) measurements presented in Fig. 1(c) and (d)
Summary
Stem cells are defined by their ability to self-renewal and differentiation into more specialized cells, depending on their level of potency [1]. MSC can differentiate into bone, cartilage, fat, tendon, and other different cell lines depending on the given conditions and growth factors [2]. There are several major issues in the therapeutic processes including the non-invasive cellular imaging in high quality transport of therapeutic agent, as well as the remote manipulation in the desired area. Our previous investigations have shown that uncoated gallium nitride nanoparticles (GaN) do not affect the viability and proliferation of endothelial cells [14] and can be used for multifunctional therapeutic purposes which include cells tracking [15]. The use of piezoelectric nanoparticles in combination with magnetic ones could increase the impact of smart materials in remote cells imaging and in the control of the cellular metabolic activity [16,17,18,19]
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