Abstract
Mesenchymal stem cells (MSCs) bear a promising potential for regenerative medicine therapies and they repair damaged tissue through secretion of immune modulatory and anti-inflammatory molecules acting in a paracrine fashion. Coronavirus disease 2019 (COVID-19) has spread all over the world with high morbidity and mortality rates and there is no specific treatment for this infection. A recent study published in the journal reports that MSC infusion is safe and effective in patients suffering from COVID-19 induced pneumonia. In the light of this study and previous reports, we make additional comments about possible therapeutic effects of MSCs in COVID-19 infection.
Highlights
Mesenchymal stem cells (MSCs) bear a promising potential for regenerative medicine therapies and they repair damaged tissue through secretion of immune modulatory and anti -inflammatory molecules acting in a paracrine fashion
Subsequent studies have shown that these cells secrete bioactive molecules such as growth factors, chemokines, cytokines and extracellular vesicles acting in a paracrine fashion and exert immune modulation and anti-inflammatory effects in tissue of interest [3]
Clinical situation of COVID-19 infection varies from mild fever to respiratory failure resulting with acute respiratory distress syndrome (ARDS) and death
Summary
Mesenchymal stem cells (MSCs) bear a promising potential for regenerative medicine therapies and they repair damaged tissue through secretion of immune modulatory and anti -inflammatory molecules acting in a paracrine fashion. Since the first discovery of mesenchymal stem cells (MSCs) by Friedenstein and colleagues in 1970s [1], their regenerative and therapeutic potential has been widely investigated in several diseases with promising results [2]. The number of patients suffering from COVID-19 infection is increasing utmost and some of them need hospitalization and/or intensive care unit (ICU) follow-up [5,6,7].
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