Abstract
Female infertility is a global medical condition that can be caused by various disorders of the reproductive system, including premature ovarian failure (POF), polycystic ovary syndrome (PCOS), endometriosis, Asherman syndrome, and preeclampsia. It affects the quality of life of both patients and couples. Mesenchymal stem cells (MSCs) have received increasing attention as a potential cell-based therapy, with several advantages over other cell sources, including greater abundance, fewer ethical considerations, and high capacity for self-renewal and differentiation. Clinical researchers have examined the therapeutic use of MSCs in female infertility. In this review, we discuss recent studies on the use of MSCs in various reproductive disorders that lead to infertility. We also describe the role of microRNAs (miRNAs) and exosomal miRNAs in controlling MSC gene expression and driving MSC therapeutic outcomes. The clinical application of MSCs holds great promise for the treatment of infertility or ovarian insufficiency, and to improve reproductive health for a significant number of women worldwide.
Highlights
Female infertility is defined as the inability to achieve any pregnancy after one year(Hull, Glazener et al, 1985) [1]
We briefly review five of the most common disorders that lead to infertility in women: premature ovarian failure (POF), polycystic ovary syndrome (PCOS), endometriosis, Asherman syndrome, and preeclampsia [3,4,5] (Figure 1)
Mesenchymal stem cells (MSCs) exert their effects through the modulation of various molecular and biological pathways. miRNAs and exosomal miRNAs in particular appear to play an important role in mediating
Summary
Female infertility is defined as the inability to achieve any pregnancy after one year (or longer). Several laboratory studies and clinical trials are investigating stem cells as a strategy for treating ovarian dysfunction and endometrial disorders that lead to infertility. Several studies have focused on mesenchymal stem cells (MSCs) as an experimental approach to restoring ovarian function and treating infertility [6,7,8,9]. We first review the various reproductive system disorders that cause infertility in women, review the progress that has been made and the remaining challenges we face in applying MSCs to the treatment of these disorders This information may help guide future laboratory experiments and clinical trials of MSCs as a promising therapy for restoring fertility, which affects a significant number of women all over the world
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
