Mesenchymal stem cell therapy for acute radiation syndrome.

Risaku Fukumoto

doi:10.1186/s40779-016-0086-1

Abstract

Acute radiation syndrome affects military personnel and civilians following the uncontrolled dispersal of radiation, such as that caused by detonation of nuclear devices and inappropriate medical treatments. Therefore, there is a growing need for medical interventions that facilitate the improved recovery of victims and patients. One promising approach may be cell therapy, which, when appropriately implemented, may facilitate recovery from whole body injuries. This editorial highlights the current knowledge regarding the use of mesenchymal stem cells for the treatment of acute radiation syndrome, the benefits and limitations of which are under investigation. Establishing successful therapies for acute radiation syndrome may require using such a therapeutic approach in addition to conventional approaches.

Highlights

Acute radiation syndrome affects military personnel and civilians following the uncontrolled dispersal of radiation, such as that caused by detonation of nuclear devices and inappropriate medical treatments
Hematopoietic stem cell (HSC) are extremely sensitive to radiation [11], suggesting that their transplantation may be considered for the treatment of hematopoietic syndrome [12]
This article of Military Medical Research features the report of Eaton and Varney [19], who illustrate the possible use of Mesenchymal stem cell (MSC) therapy for the treatment of acute radiation syndrome (ARS) from the point of view of military medicine

Summary

Introduction

Acute radiation syndrome affects military personnel and civilians following the uncontrolled dispersal of radiation, such as that caused by detonation of nuclear devices and inappropriate medical treatments. Mesenchymal stem cells (MSCs) are beneficial for the treatment of medical conditions requiring tissue regeneration. Identification of their underlying mechanisms may greatly improve the prospects of using MSC-based therapies for unmet medical needs, including the treatment of ARS.

Results

Conclusion