Abstract
MORE or less as the result of chance, bromides 1 and barbiturates 2 became known as useful drugs in the control of seizures. Good results in the treatment of patients with convulsive seizures were obtained with these two drugs and with fasting, 3 ketogenic 4 diet and dehydration. 5 However, there still remained a great number of patients who were not so benefited. Surgery and psychotherapy added to the number of patients whose seizures were brought under control. In 1937, Putnam and Merritt 6 devised an experimental procedure which resulted in a striking acceleration in the development of additional drugs for use in the control of epileptic seizures. Their clinical report, 7 which followed shortly their laboratory studies, stimulated what later proved to be a justified enthusiasm for the use of diphenylhydantoin sodium U.S.P. (dilantin ® ). With the interest in this new drug went an intensive search for other drugs
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