Mesalazine solubility in propylene glycol and water mixtures at various temperatures using a laser monitoring technique

Abstract

An updated lab-made setup is used to study mesalazine solubilization behavior in the binary mixtures of propylene glycol and water at the temperature range of 293.2–313.2 K. The solubility data are correlated with some linear and non-linear cosolvency models including the van't Hoff, the mixture response surface, the Yalkowsky, the Jouyban-Acree, the Jouyban-Acree-van't Hoff, and the modified Wilson models, and the mean relative deviations (MRD%) of the predicted solubility data by the investigated models are computed. Furthermore, the apparent thermodynamics of mesalazine dissolution process is calculated by using the van't Hoff and Gibbs equations. Moreover, by using the inverse Kirkwood-Buff integrals it is apparently observed that no preferential solvation of mesalazine is present in these mixtures.