Abstract
New antibiotics are desperately needed to overcome the societal challenges being encountered with methicillin-resistant Staphylococcus aureus (MRSA). In this study, a new tetracene derivative, named Mersaquinone (1), and the known Tetracenomycin D (2), Resistoflavin (3) and Resistomycin (4) have been isolated from the organic extract of the marine Streptomyces sp. EG1. The strain was isolated from a sediment sample collected from the North Coast of the Mediterranean Sea of Egypt. The chemical structure of Mersaquinone (1) was assigned based upon data from a diversity of spectroscopic techniques including HRESIMS, IR, 1D and 2D NMR measurements. Mersaquinone (1) showed antibacterial activity against methicillin-resistant Staphylococcus aureus with a minimum inhibitory concentration of 3.36 μg/mL.
Highlights
Methicillin-resistant Staphylococcus aureus (MRSA) is an infectious Gram-positive bacterium that is widely distributed worldwide in hospitals, convalescent homes and community settings [1]
Marine bacteria have been shown to produce compounds that inhibit the growth of methicillin-resistant Staphylococcus aureus [6,7,8,9]
Cultivation of the strain on a Waksman medium at 28 ◦ C for 7 days followed by extraction, evaporation and chromatographic purification of the organic extract led to the isolation of one new compound Mersaquinone (1) as well as the known
Summary
Methicillin-resistant Staphylococcus aureus (MRSA) is an infectious Gram-positive bacterium that is widely distributed worldwide in hospitals, convalescent homes and community settings [1]. Marine bacteria have been shown to produce compounds that inhibit the growth of methicillin-resistant Staphylococcus aureus [6,7,8,9]. Among these bacteria, actinomycetes appear to be the most prolific producers [10,11]. The marine-derived actinomycetes are known to produce compounds of unique structures with antimicrobial activities [12,13,14]. A few studies have been carried out to isolate natural compounds from marine-derived actinomycetes of the Mediterranean Sea [20,21].
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