Abstract
Ganoderma fungi have long been used as functional foods and traditional medicines in Asian countries. Ganoderma ahmadii is one of the main species of Ganoderma fungi distributed in Hainan province of China, the fruiting bodies of which have been used in folk to lower blood sugar for a long time. A chemical investigation of the fruiting bodies of Ganoderma ahmadii led to the isolation of seven new meroterpenoids, named ganoduriporols F-L (1–7). The chemical structures of the compounds were elucidated by spectroscopic data including HRESIMS and 2D NMR. Compounds 5–7 represent the first examples of ganoduriporol-type meroterpenoids bearing oxepane rings in their skeletons. Compounds 1–4 showed inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) comparable to the positive control Na3VO4, with IC50 values of 17, 20, 19, and 23 μM, respectively.
Highlights
Ganoderma fungi have been widely used as functional foods and traditional medicines, which have provided more efficient means for human health care, nutrition, medical care in China (Ma et al, 2019)
Recent studies on the pathological mechanism revealed that type 2 diabetes has a close relationship with the protein tyrosine phosphatase family, which plays an important role in the negative regulator of insulin signaling by dephosphorylating the tyrosine residues of proteins (Tamrakar et al, 2014)
protein tyrosine phosphatase 1B (PTP1B) is an important member of the protein tyrosine phosphatase family
Summary
Ganoderma fungi have been widely used as functional foods and traditional medicines, which have provided more efficient means for human health care, nutrition, medical care in China (Ma et al, 2019). Previous studies have showed that the bioactive constituents of these fungi are mainly triterpenoids (Baby et al, 2015), polysaccharides (Wang et al, 2014), alkaloids (Zhao et al, 2015), and meroterpenoids (Yan et al, 2013) etc. These compounds with diverse structures displayed various biological effects, such as anti-tumor (Fu et al, 2019), anti-inflammatory (Lu et al, 2019), anti-diabetes (Wang et al, 2017), immunomodulation (Ji et al, 2007), and anti-oxidation activities (Qiu et al, 2016). PTP1B is an important member of the protein tyrosine phosphatase family
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