Abstract
Three new merosesquiterpenoids, 24-methylsulfinyllancoquinone B (1), pelorol A (2), and epi-langconol A (3), along with eight known related analogues, were isolated from a marine sponge Spongia pertusa Esper. The compounds were completely characterized by NMR spectroscopy and HRESIMS. Compound 1 had a friedo-drimane sesquiterpenoid skeleton bearing a rare 3-(methylsulfinyl)propan-1-amine functionality, whereas 2 and 3 were members of the drimane-type sesquiterpenoid derivatives. Compounds 1, 4, 6, 7, and 8 exhibited moderate antifungal activity against three human pathogens, namely, Candida albicans, Trichophyton mentaqrophytes, and Trichophyton rubrum, with MIC50 values ranging from 12.5 to 50 μg/mL.
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