Abstract
Background and aims: Patients with advanced Merkel cell carcinoma that do not respond or develop resistance to PD-1/PD-L1 axis blockade may lack sufficient tumor specific T cell responses. We sought to ask whether adoptive transfer of autologous T cells transduced with Merkel polyomavirus (MCPyV) specific T cells could lead to clinical responses in PD-1 inhibitor refractory patients. Methods: Five MCPyV positive, HLA-A02 patients with PD-1 inhibitor refractory metastatic Merkel cell carcinoma were treated with adoptive transfer of CD62L+ CD8+ and CD4+ autologous T cells transduced with a T cell receptor (TCR) targeting an HLA-A0201 restricted MCPyV epitope.
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