Abstract
The unprecedented cooperative systems involving a diarylprolinol silyl ether with various Lewis acids have been found to effect the highly enantioselective intermolecular α-alkylation of aldehydes. A wide variety of aldehydes and alcohols can be transformed into the desired highly functionalized aldehydes in high yields, excellent enantioselectivities, and good diastereoselectivities at room temperature under mild conditions.
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