Abstract
The toxicity of mercury and its compounds is widely recognized. Symptoms of mercury intoxication vary greatly depending on mode of entry, form of mercury, dose, and duration of exposure. In humans, the principal toxic effects of inorganic mercury involve the liver and kidney. Organic mercurials such as methylmercury have a more pronounced effect on the central nervous system.Pharmacological studies suggest an intestinal elimination of organic mercurials and the possibility of an intestinal lesion associated with mercury. Autoradiographic studies have indicated that uptake of 203HgCl2 by rat paneth cells exceeded that of other cells of the small intestine. Paneth cells line the bottoms of intestinal crypts. They are pyramidal in shape with basally located nuclei and large secretory granules in their apical aspect which contain the bacteriolytic enzyme lysozyme.
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Schedule a callMore From: Proceedings, annual meeting, Electron Microscopy Society of America
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